DMPK Scientist

My client is the premiere pharma firm in the Southeast in the small- to mid-sized category. Their pipeline of small molecule NCEs boasts first-in-class agents for various medical disorders. This highly-regarded, growing firm needs your expert pharmaceutical development experience to expand their product portfolio.

To explore opportunities with this excellent innovator firm, please apply by submitting a resume (in MS Word format, please) and a cover letter detailing prior, relevant experience to: [Click here for email]

Description:
This position reports to a Group Leader in the Bioanalytical/DMPK group.

The primary responsibilities of this position are generating, validating and performing in vitro analytical methods for determination of ADME properties of small molecule new chemical entities (NCEs), meeting all regulatory requirements, working independently at the bench and representing the Bioanalytical and Drug Metabolism function at project team meetings.
REQUIREMENTS
Requirements:
-M.S. in Chemistry or Biochemistry or very closely related field, with a minimum of six years of relevant experience, or Ph.D. in Chemistry or Biochemistry or related field with a minimum of two years experience.
-Experience in the bioanalytical chemistry or drug metabolism functions of pharmaceutical companies, GLP contract research organizations or equivalent companies, working with small molecules and supporting pharmaceutical industry, is preferred.
-An excellent understanding of metabolism processes and experimental equipment is necessary.
-The successful candidate will have experience with de novo design of and modification of assays to determine metabolic rate, membrane permeability and transport of pharmaceutical compounds and the identity of metabolites.
-Experience with high throughput assays, in 96-well plate formats, for analysis by LC-MS/MS, is necessary, as is familiarity with GLP requirements.
-Candidates must have excellent communication and interpersonal skills, extensive knowledge of and facility with the use of scientific software, such as data acquisition systems and calculation spreadsheets, and thorough familiarity with the formats for presentation of bioanalytical/DMPK data.

Other desirable abilities and experience include:
-Advanced knowledge of a variety in vitro metabolism assays.
-Ability to set-up, run, and perform routine maintenance for a LC-MS/MS system.
-Demonstrated ability to interpret and review data from MS/MS.
-Experience with LC and GC using various hyphenated techniques.

Keywords: small molecule, pharmaceutical, bioanalytical, DMPK, permeability, transport, bioavailability, PK, ADME, metabolite identification, assay development, LC/MS/MS, validation, GLP, high throughput, metabolism, metabolic stability, CYP, P-gp, Caco-2

To apply, please contact:
Mark McPhee, Ph.D.
512-327-8292 x110
[Click here for email]